Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | ITK | Q08881 | 3/20 | 0.34 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 6/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450532 | 1.00 | TYRO3 (0.35) | TYRO3MERTKEGFRITKBCL6 | |
| SCHEMBL3448980 | 1.00 | TYRO3 (0.35) | TYRO3MERTKEGFRITKBCL6 | |
| SCHEMBL13311680 | 0.92 | MAPT (0.36) | TYRO3MERTKEGFRBCL6MAPT | |
| SCHEMBL3374043 | 0.92 | MAPT (0.36) | TYRO3MERTKEGFRBCL6MAPT | |
| SCHEMBL3452635 | 0.88 | TYRO3 (0.36) | TYRO3MERTKEGFRAXLMAPT | |
| SCHEMBL3452633 | 0.88 | TYRO3 (0.36) | TYRO3MERTKEGFRAXLMAPT | |
| SCHEMBL13311677 | 0.82 | MARK3 (0.39) | EGFRITKMAPTSYKRAB9A | |
| SCHEMBL3450357 | 0.82 | MARK3 (0.39) | EGFRITKMAPTSYKRAB9A | |
| SCHEMBL3451907 | 0.82 | SYK (0.36) | TYRO3MERTKEGFRAXLSYK | |
| SCHEMBL3451906 | 0.82 | SYK (0.36) | TYRO3MERTKEGFRAXLSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | TYRO3 2798/4885MERTK 1743/4885EGFR 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.