Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27745506 | 0.98 | LMNA (0.32) | LMNAHSD17B10 | |
| SCHEMBL27734679 | 0.98 | LMNA (0.32) | LMNAHSD17B10 | |
| SCHEMBL3075338 | 0.94 | LMNA (0.34) | LMNAHSD17B10 | |
| SCHEMBL27696459 | 0.82 | FDPS (0.36) | LMNAHSD17B10 | |
| SCHEMBL27403746 | 0.82 | LMNA (0.42) | LMNAHSD17B10 | |
| SCHEMBL3203563 | 0.82 | CYP4F2 (0.43) | LMNAHSD17B10 | |
| SCHEMBL28320076 | 0.82 | SOAT1 (0.34) | LMNAHSD17B10 | |
| SCHEMBL9222465 | 0.82 | GAA (0.43) | — | |
| SCHEMBL29637097 | 0.80 | SMPD1 (0.42) | LMNAHSD17B10 | |
| SCHEMBL9225460 | 0.80 | GAA (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103665329-B | A kind of biotin functionalized soluble conjugated polymer and its preparation method and application | NANJING POST & TELECOMMUNICATION UNIV. (CN) | 2015-10-28 | — | — | CN | claimed |
| CN-103665329-A | Biotin functionalized water-soluble conjugated polymer as well as preparation method and application thereof | UNIV NANJING POSTS & TELECOMM | 2014-03-26 | — | — | CN | claimed |
| CN-106164072-B | Monocyclic lactam organic compounds for the treatment of bacterial infections | 诺华股份有限公司 | 2019-10-01 | — | — | CN | disclosed |
| US-10208062-B2 | Macrocyclic quinazole derivatives and their use as MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-19 | — | — | US | disclosed |
| US-20170320894-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-09 | — | — | US | disclosed |
| US-9688691-B2 | Macrocyclic quinazole derivatives and their use as MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-27 | — | — | US | disclosed |
| CN-106164072-A | Monocyclic lactam organic compounds for the treatment of bacterial infections | 诺华股份有限公司 | 2016-11-23 | — | — | CN | disclosed |
| EP-1828201-B1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-11 | — | — | EP | disclosed |
| CN-103665329-B | A kind of biotin functionalized soluble conjugated polymer and its preparation method and application | NANJING POST & TELECOMMUNICATION UNIV. (CN) | 2015-10-28 | — | — | CN | disclosed |
| US-20140256714-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-11 | — | — | US | disclosed |
| CN-103665329-A | Biotin functionalized water-soluble conjugated polymer as well as preparation method and application thereof | UNIV NANJING POSTS & TELECOMM | 2014-03-26 | — | — | CN | disclosed |
| CN-101951913-A | Poly aromatic sodium channel blockers | PARION SCIENCES INC | 2011-01-19 | — | — | CN | disclosed |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN-CILAG (FR) | 2010-06-17 | — | — | US | disclosed |
| CN-1764650-B | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP | 2010-06-16 | — | — | CN | disclosed |
| CN-101525339-A | Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB | 2009-09-09 | — | — | CN | disclosed |
| CN-101243093-A | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | disclosed |
| EP-1828201-A2 | MACROCYCLIC QUINAZOLINE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-05 | — | — | EP | disclosed |
| CN-1968956-A | Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2007-05-23 | — | — | CN | disclosed |
| WO-2006061417-A2 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-15 | — | — | WO | disclosed |
| CN-1764650-A | 2, 3, 6-trisubstituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORP (JP) | 2006-04-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256714-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR3C2, NR1I2 | LMNA 3140/4885HSD17B10 385/4885 |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR1I2, NR3C2 | LMNA 3597/4885HSD17B10 217/4885 |
| US-20170320894-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR3C2, NR1I2 | LMNA 3140/4885HSD17B10 385/4885 |
| US-10208062-B2 | Macrocyclic quinazole derivatives and their use as MTKI | NR1I3, NR3C2, NR1I2 | LMNA 3140/4885HSD17B10 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.