Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.43 |
| ▸ | STK17B | O94768 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449743 | 1.00 | STK17A (0.43) | STK17ASTK17BHDAC1HDAC8HDAC6 | |
| SCHEMBL3448134 | 0.96 | STK17A (0.40) | STK17ASTK17BHDAC1HDAC8HDAC6 | |
| SCHEMBL3448130 | 0.96 | STK17A (0.40) | STK17ASTK17BHDAC1HDAC8HDAC6 | |
| SCHEMBL13348324 | 0.92 | GSK3B (0.38) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL13311016 | 0.91 | STK17A (0.42) | STK17ASTK17BHDAC1HDAC8HDAC6 | |
| SCHEMBL13310986 | 0.87 | STK17A (0.39) | STK17ASTK17BHDAC1HDAC8HDAC6 | |
| SCHEMBL13348470 | 0.87 | STK17A (0.39) | STK17ASTK17BHDAC1HDAC8HDAC6 | |
| SCHEMBL3449476 | 0.84 | STK17A (0.46) | STK17ASTK17BSOS1GSK3BALK | |
| SCHEMBL13348473 | 0.83 | MEN1 (0.37) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3450976 | 0.83 | PIM2 (0.52) | STK17ASTK17BPIM2PIM1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | STK17A 1984/4885STK17B 2457/4885HDAC1 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.