SCHEMBL3450263

SCHEMBL3450263

O=C(O)CC1COc2cc(OCc3ccc(C(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)ccc21

nearest known ligand 0.63

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 18/20 0.63
PPARD Q03181 5/20 0.61
PPARG P37231 4/20 0.61
PPARA Q07869 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22668244 0.82 PPARD (0.66) FFAR1PPARDPPARGPPARA
SCHEMBL3450675 0.81 PPARD (0.71) FFAR1PPARDPPARGPPARA
SCHEMBL15211420 0.80 FFAR1 (0.68) FFAR1PPARDPPARGPPARA
SCHEMBL13110587 0.80 PPARG (0.72) FFAR1PPARDPPARGPPARA
SCHEMBL13110586 0.79 PPARG (0.73) FFAR1PPARDPPARGPPARA
SCHEMBL13110532 0.79 FFAR1 (0.60) FFAR1PPARDPPARGPPARA
SCHEMBL3450379 0.79 FFAR1 (0.73) FFAR1PPARDPPARGPPARA
SCHEMBL2883778 0.78 FFAR1 (0.62) FFAR1PPARDPPARGPPARA
SCHEMBL10258701 0.78 FFAR1 (0.62) FFAR1PPARDPPARGPPARA
SCHEMBL15239363 0.78 FFAR1 (0.62) FFAR1PPARDPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed
US-20060258722-A1 Condensed ring compound TAKEDA PHARMACEUTICAL COMPANY., LTD. (JP) 2006-11-16 US disclosed
EP-1630152-A1 CONDENSED RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2006-03-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060258722-A1 Condensed ring compound GPR119, GLP1R, GCGR FFAR1 93/4885PPARD 74/4885PPARG 102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.