Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 4/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450826 | 1.00 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2LCKMAP3K7 | |
| SCHEMBL3449092 | 0.94 | MAP3K7 (0.43) | NPC1RAB9ASMN1; SMN2MAP3K7IRAK4 | |
| SCHEMBL3449094 | 0.94 | MAP3K7 (0.43) | NPC1RAB9ASMN1; SMN2MAP3K7IRAK4 | |
| SCHEMBL13421207 | 0.92 | MAP3K7 (0.41) | NPC1RAB9ASMN1; SMN2MAP3K7IRAK4 | |
| SCHEMBL3448829 | 0.92 | CHEK1 (0.47) | NPC1RAB9ASMN1; SMN2LCKPRKDC | |
| SCHEMBL3448832 | 0.92 | CHEK1 (0.47) | NPC1RAB9ASMN1; SMN2LCKPRKDC | |
| SCHEMBL3449191 | 0.91 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2LCKMAP3K7 | |
| SCHEMBL3449193 | 0.91 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2LCKMAP3K7 | |
| SCHEMBL3451366 | 0.91 | MAP3K7 (0.41) | NPC1RAB9ASMN1; SMN2MAP3K7IRAK4 | |
| SCHEMBL3451365 | 0.91 | MAP3K7 (0.41) | NPC1RAB9ASMN1; SMN2MAP3K7IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | NPC1 603/4885RAB9A 2449/4885SMN1; SMN2 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.