Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345954 | 0.87 | CTSK (0.46) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL9830863 | 0.84 | CTSK (0.48) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL9830861 | 0.84 | CTSK (0.48) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL347305 | 0.83 | LPAR1 (0.43) | CTSKLPAR1LPAR3OPRM1 | |
| SCHEMBL345365 | 0.83 | CTSK (0.48) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL10654631 | 0.78 | PPARA (0.46) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL371133 | 0.78 | CTSK (0.44) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL15869729 | 0.78 | CTSK (0.44) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL10654633 | 0.78 | PPARA (0.46) | CTSKHTTLPAR1LPAR3HCAR2 | |
| SCHEMBL9829305 | 0.77 | HCAR2 (0.50) | CTSKHTTLPAR1LPAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2012-01-19 | — | — | US | disclosed |
| US-8039480-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CTSK 87/4885HTT 2277/4885LPAR1 4648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.