Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449356 | 0.79 | KMT2A (0.52) | LMNACYP1A2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL1390562 | 0.78 | ALDH1A1 (0.37) | SCN10AHSD17B10ALDH1A1PRCP | |
| SCHEMBL1390847 | 0.72 | KDM4E (0.46) | HSD17B10KDM4ECYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL4107335 | 0.72 | HSD17B10 (0.61) | HRH4HRH3SCN10AHSD17B10KDM4E | |
| SCHEMBL1390854 | 0.71 | MEN1 (0.43) | KDM4ELMNAALDH1A1 | |
| SCHEMBL2505194 | 0.70 | AAK1 (0.48) | HRH4HRH3AAK1PRCP | |
| SCHEMBL2505196 | 0.70 | AAK1 (0.48) | HRH4HRH3AAK1PRCP | |
| SCHEMBL24075322 | 0.70 | AAK1 (0.48) | HRH4HRH3SCN10AHSD17B10KDM4E | |
| SCHEMBL5118214 | 0.70 | AAK1 (0.48) | HRH4HRH3SCN10AHSD17B10KDM4E | |
| SCHEMBL6986516 | 0.67 | SCN10A (0.45) | HRH4HRH3SCN10AHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029643-A1 | HETEROCYCLYC SULFONAMIDES HAVING EDG-1 ANTAGONISTIC ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029643-A1 | HETEROCYCLYC SULFONAMIDES HAVING EDG-1 ANTAGONISTIC ACTIVITY | EDF1, ERLIN1, ECE1 | HRH4 1356/4885HRH3 2004/4885EGLN1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.