Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | VCP | P55072 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450928 | 0.90 | JAK2 (0.46) | PTGS2JAK3JAK2AURKAFLT3 | |
| SCHEMBL3452008 | 0.90 | IKBKB (0.53) | JAK3JAK2AURKAIKBKB | |
| SCHEMBL3451118 | 0.90 | JAK2 (0.61) | JAK3JAK2AURKAFLT3HRH1 | |
| SCHEMBL3450888 | 0.89 | JAK2 (0.45) | PTGS2JAK3JAK2AURKAFLT3 | |
| SCHEMBL13127073 | 0.87 | JAK2 (0.43) | PTGS2JAK3JAK2AURKAFLT3 | |
| SCHEMBL3452164 | 0.87 | HRH4 (0.48) | JAK3JAK2HRH1HRH4HRH2 | |
| SCHEMBL3450957 | 0.85 | PTGS2 (0.47) | PTGS2JAK3JAK2AURKAHRH1 | |
| Hydrochloric Acid SCHEMBL3450859 | 0.84 | PTGS2 (0.46) | PTGS2JAK3JAK2AURKAHRH1 | |
| SCHEMBL3451124 | 0.84 | HRH4 (0.44) | JAK3JAK2HRH1HRH4HRH2 | |
| SCHEMBL3452120 | 0.83 | AURKA (0.48) | JAK3JAK2AURKAHRH1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | claimed |
| EP-1796673-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-06-20 | — | — | EP | claimed |
| US-20060084645-A1 | Novel pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-04-20 | — | — | US | claimed |
| WO-2006034473-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-03-30 | — | — | WO | claimed |
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |
| WO-2008137533-A1 | METHODS AND COMPOSITIONS FOR UPREGULATION OF GATA ACTIVITY | REDDY US THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| US-20080275049-A1 | Methods and Compositions for Upregulation of GATA Activity | REDDY US THERAPEUTICS, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080275049-A1 | Methods and Compositions for Upregulation of GATA Activity | REDDY US THERAPEUTICS, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| EP-1796673-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| US-20060084645-A1 | Novel pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-04-20 | — | — | US | disclosed |
| WO-2006034473-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084645-A1 | Novel pyrimidine compounds, process for their preparation and compositions containing them | UMPS, DPYD, TYMS | PTGS2 1220/4885JAK3 2746/4885JAK2 1205/4885 |
| US-20080275049-A1 | Methods and Compositions for Upregulation of GATA Activity | GATAD2B, GATAD2A, RUNX1 | PTGS2 1403/4885JAK3 2442/4885JAK2 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.