Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078298 | 0.90 | MPO (0.52) | MPOKDM4EHSD17B10PTGS1AKR1C3 | |
| SCHEMBL4621271 | 0.88 | MPO (0.62) | MPOKDM4EGLAHSD17B10ABCB1 | |
| SCHEMBL20235191 | 0.87 | NQO2 (0.50) | MPOKDM4EGLAHSD17B10PTGS1 | |
| SCHEMBL9482430 | 0.87 | MPO (0.64) | MPOKDM4EGLAABCB1MAPT | |
| SCHEMBL4622222 | 0.85 | MPO (0.63) | MPOKDM4EGLAABCB1MAPT | |
| SCHEMBL6325529 | 0.81 | MPO (0.59) | MPOKDM4EGLAHSD17B10MAPT | |
| SCHEMBL7820683 | 0.79 | NQO2 (0.61) | MPOKDM4EHSD17B10PTGS1AKR1C3 | |
| SCHEMBL3451418 | 0.79 | AKR1B1 (0.56) | MPOCYP26A1MIF | |
| SCHEMBL15818200 | 0.79 | MPO (0.74) | MPOKDM4EABCB1MAPTELANE | |
| SCHEMBL5343932 | 0.78 | SRD5A1 (0.50) | MPOSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820837-B2 | ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-26 | — | — | US | disclosed |
| EP-1630152-A1 | CONDENSED RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2006-03-01 | — | — | EP | disclosed |
| EP-0461958-B1 | 2-(aminoalkyl)-5-(arylalkyl)1,3-dioxanderivatives their production and their use in therapeutics | SYNTHELABO (FR) | 1994-09-14 | — | — | EP | disclosed |
| EP-0461958-A1 | 2-(aminoalkyl)-5-(arylalkyl)1,3-dioxanderivatives their production and their use in therapeutics | SYNTHELABO (FR) | 1991-12-18 | — | — | EP | disclosed |