Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452288 | 0.88 | MPO (0.67) | MPOABCB1KDM4EGLASMN1; SMN2 | |
| SCHEMBL4622222 | 0.87 | MPO (0.63) | MPOABCB1KDM4EGLASMN1; SMN2 | |
| SCHEMBL9482430 | 0.83 | MPO (0.64) | MPOABCB1KDM4EGLASMN1; SMN2 | |
| SCHEMBL4621291 | 0.79 | MAOB (0.45) | ACHE | |
| SCHEMBL10078298 | 0.78 | MPO (0.52) | MPOABCB1KDM4ESMN1; SMN2CA1 | |
| SCHEMBL15818200 | 0.76 | MPO (0.74) | MPOABCB1KDM4EMAPTMETAP1 | |
| SCHEMBL20235191 | 0.75 | NQO2 (0.50) | MPOKDM4EGLASMN1; SMN2MAPT | |
| SCHEMBL6325529 | 0.75 | MPO (0.59) | MPOKDM4EGLASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL11078111 | 0.75 | MPO (0.72) | MPOABCB1KDM4EMAPTELANE | |
| SCHEMBL10078296 | 0.74 | MPO (0.51) | MPOABCB1KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11310561-A | — | — | None | — | — | JP | disclosed |
| EP-1270545-B1 | PROCESS FOR PRODUCING AMINE DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2008-11-05 | — | — | EP | disclosed |
| EP-0971878-B1 | AMINE COMPOUNDS, THEIR PRODUCTION AND USE AS AMYLOID-BETA PRODUCTION INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-26 | — | — | EP | disclosed |
| US-7256204-B2 | Amine compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-14 | — | — | US | disclosed |
| US-6784314-B2 | HAVING THE ACTION OF INHIBITING THE SECRETION AND ACCUMULATION OF AMYLOID BETA PROTEIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-08-31 | — | — | US | disclosed |
| US-20040077867-A1 | Amine compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-22 | — | — | US | disclosed |
| US-6613805-B2 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-02 | — | — | US | disclosed |
| US-20030139602-A1 | Process for producing amine derivatives | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2003-07-24 | — | — | US | disclosed |
| EP-1270545-A1 | PROCESS FOR PRODUCING AMINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-20020032189-A1 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | THE UNIVERSITY OF TOKYO (JP) | 2002-03-14 | — | — | US | disclosed |
| US-6310107-B1 | (+)-6-(4-BIPHENYLYL)METHOXY-2-(2-(N,N-DIMETHYLAMINO)ETHYL)TETR ALIN, OR A SALT IS USEFUL FOR INHIBITING PRODUCTION AND/OR SECRETION OF AMYLOID-BETA PROTEIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-30 | — | — | US | disclosed |
| JP-H11310561-A | PRODUCTION OF OPTICAL ISOMER | TAKEDA CHEM IND LTD | 1999-11-09 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032189-A1 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | PARK7, PSEN1, PRNP | MPO 4207/4885ABCB1 1439/4885KDM4E 3490/4885 |
| US-20040077867-A1 | Amine compounds, their production and use | QSOX1, APP, NPR1 | MPO 897/4885ABCB1 1536/4885KDM4E 2320/4885 |
| US-20030139602-A1 | Process for producing amine derivatives | APP, BACE1, IAPP | MPO 2716/4885ABCB1 2623/4885KDM4E 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.