Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | IDO1 | P14902 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451303 | 0.84 | ALDH1A1 (0.62) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL3264451 | 0.83 | ALDH1A1 (0.69) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL3453120 | 0.82 | ALDH1A1 (0.59) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL1047831 | 0.81 | ALDH1A1 (0.66) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL3264458 | 0.81 | IDO1 (0.56) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL1050492 | 0.80 | ALDH1A1 (1.00) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL1049215 | 0.74 | MAPT (0.68) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL3262533 | 0.74 | IDO1 (0.51) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL29611992 | 0.71 | IDO1 (0.59) | ALDH1A1GAAMAPTIDO1LMNA | |
| SCHEMBL19760706 | 0.71 | IDO1 (0.59) | ALDH1A1GAAMAPTIDO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820691-B2 | Indoloquinoline compounds as calcium channel blockers | MEDIPROPHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| EP-2063891-A2 | INDOLOQUINOLINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Medipropharma, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008027182-A2 | INDOLOQUINOLINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | MEDIPROPHARMA, INC. (US) | 2008-03-06 | — | — | WO | disclosed |
| US-20080051426-A1 | Indoloquinoline compounds as calcium channel blockers | MEDIPROPHARMA, INC. | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051426-A1 | Indoloquinoline compounds as calcium channel blockers | CACNA1B, CACNA1C, CACNA1G | ALDH1A1 2903/4885GAA 2729/4885MAPT 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.