Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 6/20 | 0.46 |
| ▸ | PLG | P00747 | 4/20 | 0.46 |
| ▸ | PLAT | P00750 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454219 | 0.88 | MEP1B (0.48) | PARP10PLAUF2F10F7 | |
| SCHEMBL3031503 | 0.88 | PARP1 (0.54) | PLAUPLGPLATHSD17B2PARP1 | |
| SCHEMBL3034523 | 0.81 | MAOB (0.52) | PARP10PLAUPARP1HPGD | |
| SCHEMBL3454128 | 0.78 | MMP13 (0.56) | PLAUPLGPLATF2KLKB1 | |
| SCHEMBL3453561 | 0.76 | PARP10 (0.49) | PARP10PLAUF2F10F7 | |
| SCHEMBL3025882 | 0.75 | HSD17B2 (0.61) | PLAUPLGPLATHSD17B2PARP1 | |
| SCHEMBL3455277 | 0.75 | MEN1 (0.49) | PARP10PLAUPLATF2F10 | |
| SCHEMBL3453878 | 0.74 | LCK (0.47) | PARP10PLAUF2F10F7 | |
| SCHEMBL3454125 | 0.74 | PLAU (0.43) | PARP10PLAUPLGPLATF2 | |
| SCHEMBL3454177 | 0.74 | LCK (0.44) | PARP10PLAUF2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |