Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 9/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CFD | P00746 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3641509 | 0.93 | HDAC2 (0.76) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3029792 | 0.87 | HDAC8 (0.86) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3345753 | 0.84 | FAAH (0.53) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL5943847 | 0.83 | HDAC8 (0.78) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL13073721 | 0.81 | HDAC2 (0.71) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6842122 | 0.81 | HDAC2 (0.80) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3640690 | 0.81 | NPC1 (0.64) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL17892226 | 0.80 | SLC7A5 (0.56) | MEN1KMT2A | |
| SCHEMBL1347867 | 0.80 | OPRM1 (0.62) | HDAC1ALDH1A1FAAHKDM4EMEN1 | |
| SCHEMBL3341545 | 0.80 | OPRM1 (0.62) | HDAC1ALDH1A1FAAHKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |