Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 12/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454086 | 1.00 | HTR2A (0.52) | HTR2AHTR1ADRD3DRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1970321 | 0.99 | HTR2A (0.51) | HTR2AHTR1ADRD3DRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1970325 | 0.99 | HTR2A (0.51) | HTR2AHTR1ADRD3DRD2HTR7 | |
| SCHEMBL13013944 | 0.92 | HTR2A (0.56) | HTR2AHTR1ADRD3DRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1970211 | 0.91 | HTR2A (0.55) | HTR2AHTR1ADRD3DRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1970209 | 0.91 | HTR2A (0.55) | HTR2AHTR1ADRD3DRD2HTR7 | |
| SCHEMBL14748229 | 0.89 | HTR2A (0.51) | HTR2AHTR1ADRD3DRD2HTR7 | |
| SCHEMBL13013938 | 0.87 | HTR2A (0.50) | HTR2AHTR1ADRD3DRD2HTR7 | |
| SCHEMBL14735719 | 0.87 | HTR2A (0.53) | HTR2AHTR1ADRD3DRD2HTR7 | |
| SCHEMBL14735718 | 0.87 | HTR2A (0.53) | HTR2AHTR1ADRD3DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-7858630-B2 | D3 and 5-HT2A receptor modulators | HOFFMANN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100075983-A1 | D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN-LA ROCHE, INC. | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075983-A1 | D3 AND 5-HT2A RECEPTOR MODULATORS | HTR2A, HTR3A, HTR1A | HTR2A 1/4885HTR1A 3/4885DRD3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.