Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 5/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | BLVRB | P30043 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454091 | 0.90 | SCD (0.40) | SMN1; SMN2TARBP2KDM4ERAB9AGAA | |
| SCHEMBL3454224 | 0.89 | LMNA (0.46) | SMN1; SMN2KDM4ERAB9AGAAKMT2A | |
| SCHEMBL3454095 | 0.85 | SCD (0.50) | NPC1 | |
| SCHEMBL3454854 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2TARBP2KDM4ERAB9AGAA | |
| SCHEMBL3454195 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2TARBP2KDM4ERAB9AGAA | |
| SCHEMBL3455505 | 0.82 | SCD (0.48) | NPC1 | |
| SCHEMBL3454951 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2TARBP2KDM4ERAB9AGAA | |
| SCHEMBL3454105 | 0.79 | LMNA (0.44) | SMN1; SMN2KDM4ERAB9AGAAKMT2A | |
| SCHEMBL3478653 | 0.76 | SCD (0.59) | — | |
| SCHEMBL3454096 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2TARBP2KDM4ERAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143597-A9 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | claimed |
| WO-2007143597-A9 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | disclosed |