Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454890 | 0.92 | AVPR2 (0.65) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL15712623 | 0.88 | HPGD (0.68) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL11031260 | 0.84 | HPGD (0.69) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL3461334 | 0.83 | BRD4 (0.56) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL8620609 | 0.82 | HPGD (0.68) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL31556814 | 0.81 | HPGD (1.00) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL5783412 | 0.81 | HPGD (1.00) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL28771923 | 0.80 | RAB9A (0.65) | HPGDALDH1A1AVPR2AVPR1ARAB9A | |
| SCHEMBL3462953 | 0.79 | NPC1 (0.70) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21348490 | 0.79 | HPGD (0.62) | HPGDALDH1A1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735584-B2 | Protein kinase inhibitors and use thereof | MERCK PATENT GMBH (DE) | 2014-05-27 | — | — | US | disclosed |
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |
| US-20110053906-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-03-03 | — | — | US | disclosed |
| EP-2254889-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | Merck Patent GmbH (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009108670-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2009-09-03 | — | — | WO | disclosed |
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |
| EP-0127634-A1 | PYRROLOCOUMARIN DERIVATIVES, THEIR MANUFACTURE AND UTILISATION | KATHOLIEKE UNIVERSITEIT TE LEUVEN (BE) | 1984-12-12 | — | — | EP | disclosed |
| WO-1984002133-A1 | PYRROLOCOUMARIN DERIVATIVES, THEIR MANUFACTURE AND UTILISATION | UNIV LEUVEN KATH (BE) | 1984-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053906-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP4K2, MAP3K20, MAP4K1 | HPGD 2363/4885ALDH1A1 4501/4885AVPR2 4726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.