Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455157 | 0.87 | KDM4E (0.52) | MAPTKDM4EMAOBHPGDLMNA | |
| SCHEMBL15049279 | 0.87 | TRPM8 (0.60) | TRPM8MAPTKDM4EALDH1A1MAOB | |
| SCHEMBL9795318 | 0.84 | MAPT (0.54) | MAPTKDM4EALDH1A1MAOBHPGD | |
| SCHEMBL15049165 | 0.83 | TRPM8 (0.62) | TRPM8MAPTMAOBKMT2AMEN1 | |
| SCHEMBL15049051 | 0.80 | TRPM8 (0.67) | TRPM8MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1968418 | 0.76 | TRPM8 (0.65) | TRPM8MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL20654264 | 0.76 | NPC1 (0.51) | TRPM8MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL28047041 | 0.75 | MAPT (0.52) | TRPM8MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL15049355 | 0.74 | TRPM8 (0.68) | TRPM8MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL28884890 | 0.74 | MAPT (0.51) | TRPM8MAPTKDM4EALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |