Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047081 | 0.88 | MAPT (0.47) | MAPTKDM4ETRPM8CDC7DBF4 | |
| SCHEMBL28047023 | 0.85 | RHEB (0.42) | MAPTKDM4EALDH1A1KMT2ANPC1 | |
| SCHEMBL28047003 | 0.84 | MAPT (0.46) | MAPTKDM4ETRPM8CDC7DBF4 | |
| SCHEMBL3455065 | 0.75 | TRPM8 (0.52) | MAPTKDM4ETRPM8ALDH1A1KMT2A | |
| SCHEMBL28117752 | 0.75 | GPBAR1 (0.50) | MAPTKDM4ECDC7DBF4NPSR1 | |
| SCHEMBL929854 | 0.74 | CDC7 (0.53) | MAPTKDM4ETRPM8CDC7DBF4 | |
| SCHEMBL2218115 | 0.73 | MAPT (0.43) | MAPTKDM4ENPSR1GAAGPR55 | |
| SCHEMBL2215954 | 0.73 | GPBAR1 (0.61) | MAPTALDH1A1HPGD | |
| SCHEMBL1966993 | 0.73 | MAPT (0.62) | MAPTKDM4ETRPM8CDC7DBF4 | |
| SCHEMBL5651486 | 0.72 | CDC7 (0.59) | MAPTKDM4ECDC7DBF4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164112-A | Amide compound and preparation method, pharmaceutical composition and application thereof | SHANGHAI INST MATERIA MEDICA | 2015-12-16 | — | — | CN | disclosed |