Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL28475068 | 0.97 | KDM4E (0.54) | GLRA1SLC6A9OR51E2KDM4ELMNA | |
| Bicarbonate SCHEMBL27949760 | 0.92 | MGAM (0.52) | GLRA1SLC6A9OR51E2KDM4ELMNA | |
| SCHEMBL13169650 | 0.91 | — | — | |
| SCHEMBL12140935 | 0.91 | — | — | |
| SCHEMBL2148 | 0.91 | — | — | |
| Succinic Acid SCHEMBL28067631 | 0.90 | TSHR (0.56) | GLRA1SLC6A9OR51E2KDM4ELMNA | |
| Acetic Acid SCHEMBL19468 | 0.89 | MGAM (0.57) | GLRA1SLC6A9OR51E2KDM4ELMNA | |
| Acetic Acid SCHEMBL27471902 | 0.89 | MGAM (0.57) | GLRA1SLC6A9OR51E2KDM4ELMNA | |
| Acetic Acid SCHEMBL7017383 | 0.89 | MGAM (0.57) | GLRA1SLC6A9OR51E2KDM4ELMNA | |
| Oxalic Acid SCHEMBL30540157 | 0.89 | LMNA (0.50) | GLRA1SLC6A9OR51E2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193115-A1 | COMPOUND, DIAGNOSTIC AGENT, NUCLEAR MAGNETIC RESONANCE ANALYSIS METHOD, NUCLEAR MAGNETIC RESONANCE IMAGING METHOD, MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY IMAGING METHOD | Kyoto University (JP) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009031712-A1 | COMPOUND, DIAGNOSTIC AGENT, NUCLEAR MAGNETIC RESONANCE ANALYSIS METHOD, NUCLEAR MAGNETIC RESONANCE IMAGING METHOD, MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY IMAGING METHOD | KYOTO UNIVERSITY (JP) | 2009-03-12 | — | — | WO | disclosed |