Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL4405044 | 1.00 | ALPI (0.45) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL6461209 | 1.00 | ALPI (0.45) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL21878868 | 0.97 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL3099767 | 0.97 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL1675279 | 0.97 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL28033410 | 0.94 | ALPI (0.43) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL28854621 | 0.94 | OPRK1 (0.42) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL2764420 | 0.92 | SLC7A5 (0.54) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL4612447 | 0.92 | SLC7A5 (0.54) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL10428633 | 0.92 | SLC7A5 (0.54) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530181-B2 | Method of screening for compounds which affect the cleavage of EphA7 byγ-secretase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-10 | — | — | US | disclosed |
| EP-2219028-B1 | SCREENING METHOD UTILIZING NOVEL SUBSTRATE EPHA7 FOR GAMMA-SECRETASE | EISAI R&D MAN CO LTD (JP) | 2012-09-12 | — | — | EP | disclosed |
| US-20100255522-A1 | Screening Method Utilizing Novel Substrate EphA7 for Gamma-Secretase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2219028-A1 | SCREENING METHOD UTILIZING NOVEL SUBSTRATE EphA7 FOR gamma-SECRETASE | Eisai R&D Management Co., Ltd. (JP) | 2010-08-18 | — | — | EP | disclosed |