Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | CPA3 | P15088 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL1675279 | 0.95 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL21878868 | 0.95 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL3099767 | 0.95 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL6461209 | 0.94 | ALPI (0.45) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL3455496 | 0.94 | ALPI (0.45) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL4405044 | 0.94 | ALPI (0.45) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL28854621 | 0.88 | OPRK1 (0.42) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Tyrosine SCHEMBL15264616 | 0.87 | SLC7A5 (0.50) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Tyrosine SCHEMBL7434891 | 0.87 | SLC7A5 (0.50) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL4287099 | 0.87 | KMT2A (0.37) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087444-B | Mass spectrum probe for DPP-4 activity detection and preparation method and application thereof | 浙江大学 | 2021-08-24 | — | — | CN | disclosed |
| CN-111087444-A | Mass spectrum probe for DPP-4 activity detection and preparation method and application thereof | 浙江大学 | 2020-05-01 | — | — | CN | disclosed |
| CN-110698539-A | Mass spectrum probe for DPP-4 activity detection and preparation method and application thereof | 浙江大学 | 2020-01-17 | — | — | CN | disclosed |
| CN-105061557-A | Polypeptide for DPP-4 detection and fluorescence probe containing polypeptide | UNIV ZHEJIANG | 2015-11-18 | — | — | CN | disclosed |