Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454511 | 0.87 | CDC7 (0.52) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL3454811 | 0.84 | SCD (0.56) | SMN1; SMN2GAAALDH1A1NPC1HPGD | |
| SCHEMBL3454096 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL3454854 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL3455438 | 0.78 | PPARD (0.54) | SMN1; SMN2RAB9AKDM4EGAANPC1 | |
| SCHEMBL3454195 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL1327631 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL289112 | 0.74 | SMN1; SMN2 (0.93) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL3454331 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AKDM4EGAAKMT2A | |
| SCHEMBL289371 | 0.72 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9AKDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143597-A9 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | claimed |
| WO-2007143597-A9 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| EP-2029572-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007143597-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |