Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464721 | 0.84 | PIK3CA (0.35) | LRRK2PDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL3067369 | 0.74 | MAPT (0.34) | LRRK2MELKPDE3BPDE3AMAPT | |
| SCHEMBL19139501 | 0.67 | SIGMAR1 (0.48) | LRRK2MAPTALDH1A1MEN1HTT | |
| SCHEMBL7082120 | 0.67 | ADRB1 (0.63) | MAPTALDH1A1MEN1HTTKMT2A | |
| Hydrochloric Acid SCHEMBL28769210 | 0.65 | ADRB1 (0.61) | MAPTALDH1A1MEN1HTTKMT2A | |
| Bromide SCHEMBL6539744 | 0.65 | ADRB1 (0.61) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL23410248 | 0.64 | HRH1 (0.53) | LRRK2MAPTALDH1A1MEN1HTT | |
| SCHEMBL27569317 | 0.64 | GBA1 (0.53) | LRRK2MELKMAPTALDH1A1MEN1 | |
| SCHEMBL3065789 | 0.63 | JAK2 (0.48) | LRRK2MELKMAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4767983 | 0.62 | GBA1 (0.51) | LRRK2MELKMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |