Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464052 | 0.81 | KDM4E (0.48) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL2877889 | 0.80 | MAPT (0.47) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL19852371 | 0.77 | KDM4E (0.56) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL12156542 | 0.74 | CYP2C19 (0.47) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL11489301 | 0.74 | MAPT (0.46) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL12276606 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL2877908 | 0.72 | HRH1 (0.45) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL947365 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL29683518 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL907623 | 0.71 | MAPT (0.45) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2414358-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| WO-2010114902-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114902-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | MKI67, THPO, DPYD | ALDH1A1 1357/4885KDM4E 458/4885MAPT 2753/4885 |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | MKI67, THPO, DPYD | ALDH1A1 1357/4885KDM4E 458/4885MAPT 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.