Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 3/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809114 | 0.87 | MAPT (0.46) | LMNANR1H4BLMPMP22 | |
| SCHEMBL6671659 | 0.80 | NR1H4 (0.42) | NR1H4RARBTSHREPHX2SMN1; SMN2 | |
| SCHEMBL3456546 | 0.76 | BLM (0.53) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL3456745 | 0.74 | NR1H4 (0.41) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL17111856 | 0.73 | RXRA (0.41) | PTGS1LMNAAKR1C3NR1H4TSHR | |
| SCHEMBL27959311 | 0.71 | PTGS1 (0.60) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL452233 | 0.71 | PTGS1 (0.60) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL5973107 | 0.71 | CA1 (0.44) | CYP2C9TSHRGAA | |
| SCHEMBL977243 | 0.71 | PPARA (0.52) | — | |
| SCHEMBL8793404 | 0.70 | PTGS1 (0.61) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258700-A1 | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof | Pfizer Products Inc. (US) | 2010-12-08 | — | — | EP | disclosed |