Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | ACACB | O00763 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365621 | 0.82 | CYP2C19 (0.59) | NLRP3SMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL3458300 | 0.81 | ALDH1A1 (0.55) | NLRP3SMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL4705977 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL2795102 | 0.80 | ACACB (0.47) | NLRP3SMN1; SMN2ALDH1A1ACACBKDM4E | |
| SCHEMBL10191907 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1MAPK1HPGDKDM4E | |
| SCHEMBL7752820 | 0.78 | ACACB (0.47) | NLRP3SMN1; SMN2ACACBKDM4EMEN1 | |
| SCHEMBL3457239 | 0.75 | ACACB (0.47) | NLRP3SMN1; SMN2ALDH1A1ACACBHPGD | |
| SCHEMBL4308490 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL9495103 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1MAPK1HPGDKDM4E | |
| SCHEMBL2791056 | 0.74 | ACACB (0.46) | NLRP3SMN1; SMN2ALDH1A1ACACBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256107-A1 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | Wyeth LLC (US) | 2010-12-01 | — | — | EP | disclosed |
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| US-7423158-B2 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase | WYETH (US) | 2008-09-09 | — | — | US | disclosed |
| US-7423158-B2 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase | WYETH (US) | 2008-09-09 | — | — | US | disclosed |
| US-20070072925-A1 | Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase | WYETH (US) | 2007-03-29 | — | — | US | disclosed |
| US-20070072925-A1 | Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase | WYETH (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | NLRP3 3401/4885SMN1; SMN2 1523/4885ALDH1A1 1913/4885 |
| US-20070072925-A1 | Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase | BACE1, BACE2, APP | NLRP3 3155/4885SMN1; SMN2 1525/4885ALDH1A1 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.