Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 10/20 | 0.51 |
| ▸ | BACE1 | P56817 | 10/20 | 0.51 |
| ▸ | BCHE | P06276 | 8/20 | 0.51 |
| ▸ | HTR5A | P47898 | 2/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457686 | 0.88 | ACHE (0.64) | HRH3MEN1KMT2ARAB9AACHE | |
| SCHEMBL3456705 | 0.85 | ACHE (0.65) | HRH3MEN1KMT2ARAB9AACHE | |
| SCHEMBL13989041 | 0.83 | ACHE (0.53) | HRH3MEN1KMT2ARAB9AACHE | |
| SCHEMBL21235736 | 0.81 | CARM1 (0.50) | HRH3MEN1KMT2ARAB9AACHE | |
| SCHEMBL3457683 | 0.80 | ACHE (0.54) | HRH3MEN1KMT2ARAB9AACHE | |
| SCHEMBL4716957 | 0.79 | ACHE (0.47) | HRH3MEN1KMT2AACHEBACE1 | |
| SCHEMBL4717433 | 0.77 | ACHE (0.50) | HRH3MEN1KMT2ARAB9AACHE | |
| SCHEMBL4849455 | 0.77 | ACHE (0.44) | HRH3MEN1KMT2AACHEBACE1 | |
| SCHEMBL4036091 | 0.75 | ACHE (0.59) | MEN1KMT2AACHEBACE1BCHE | |
| SCHEMBL17335877 | 0.75 | HRH3 (0.72) | HRH3MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258688-B1 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM LTD (GB) | 2012-11-21 | — | — | EP | disclosed |
| EP-2258688-A1 | Pyridinone derivatives for treatment of atherosclerosis | SmithKline Beecham Limited (GB) | 2010-12-08 | — | — | EP | disclosed |
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |
| US-20050014793-A1 | Pyridinone derivatives for treatment of atherosclerosis | GLAXO GROUP LIMITED (GB) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014793-A1 | Pyridinone derivatives for treatment of atherosclerosis | PNPO, PLA2G7, PLA2G4B | HRH3 1754/4885MEN1 3563/4885KMT2A 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.