SCHEMBL345696

SCHEMBL345696

O=c1c(O)c(-c2ccc(O)cc2)oc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 13/20 1.00
KMT2A Q03164 13/20 1.00
CYP3A4 P08684 12/20 1.00
HSD17B10 Q99714 10/20 1.00
MAPK1 P28482 7/20 1.00
ALDH1A1 P00352 7/20 1.00
HPGD P15428 7/20 1.00
ALOX15 P16050 5/20 1.00
USP2 O75604 2/20 1.00
FTO Q9C0B1 2/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
KDM4E B2RXH2 14/20 0.81
TP53 P04637 9/20 0.81
LMNA P02545 4/20 0.81
PKM P14618 2/20 0.81
CA12 O43570 1/20 0.81
CA1 P00915 1/20 0.81
CA2 P00918 1/20 0.81
ABCB1 P08183 1/20 0.81
CALM1 P0DP23 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2746872 0.95 MEN1 (0.90) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL27595696 0.92 KDM4E (0.90) MEN1KMT2ACYP3A4HSD17B10MAPK1
Chrysene SCHEMBL29180387 0.90 CYP3A4 (0.81) MEN1KMT2ACYP3A4HSD17B10MAPK1
SCHEMBL76636 0.90 KDM4E (0.93) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL1679068 0.90 KDM4E (1.00) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL29433939 0.90 KDM4E (1.00) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL20246 0.90 KDM4E (1.00) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL31570209 0.88 KDM4E (0.97) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL31328341 0.88 KDM4E (0.97) MEN1KMT2ACYP3A4HSD17B10MAPK1
Flavonol SCHEMBL21874433 0.88 KDM4E (0.97) MEN1KMT2ACYP3A4HSD17B10MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119604294-A ERbeta estrogenic compounds and methods of use 益特瑞恩公司 2025-03-11 CN claimed
CN-115032256-B Method for distinguishing chrysin and isomer 3,4' -dihydroxyflavone thereof 安徽大学 2024-04-02 CN claimed
US-20230003721-A1 MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2023-01-05 US claimed
CN-115032256-A Method for distinguishing chrysin and isomer 3, 4' -dihydroxyflavone thereof 安徽大学 2022-09-09 CN claimed
US-20200123673-A1 ELECTROLYTIC TIN ALLOY PLATING SOLUTION C. UYEMURA & CO., LTD. (JP) 2020-04-23 US claimed
WO-2019198962-A1 METHOD FOR PROMOTING PROLIFERATION AND DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS PREPARED FROM URINE-DERIVED STEM CELLS 건국대학교 산학협력단 2019-10-17 WO claimed
US-7897637-B2 Methods of using flavonoids to enhance memory THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2011-03-01 US claimed
WO-2008011538-A2 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-01-24 WO claimed
US-20080021096-A1 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2008-01-24 US claimed
US-12534742-B2 Compound for regulating gene editing efficiency and application thereof SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) 2026-01-27 US disclosed
US-20250263774-A1 DISCOVERING NEW XENOBIOTIC SUBSTRATES OF AN UDP-GLYCOSYLTRANSFERASE WITH A HIGH-THROUGHPUT METHOD UNIV NORTH TEXAS (US) 2025-08-21 US disclosed
US-12368049-B2 Protective film agent and processing method of workpiece DISCO CORPORATION (JP) 2025-07-22 US disclosed
US-20250195452-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE IATERION, INC. 2025-06-19 US disclosed
EP-4561582-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE Iaterion, Inc. (US) 2025-06-04 EP disclosed
WO-2008011538-A2 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-01-24 WO disclosed
EP-1856085-A1 FLAVONOID COMPOUNDS AND USES THEREOF Howard Florey Institute of Experimental Physiology and Medicine (AU) 2007-11-21 EP disclosed
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof EASTMAN CHEMICAL COMPANY 2007-11-01 US disclosed
WO-2007115181-A2 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEMICAL COMPANY (US) 2007-10-11 WO disclosed
WO-2007082178-A2 PROSTAGLANDIN REDUCTASE INHIBITORS ABGENOMICS CORPORATION (TW) 2007-07-19 WO disclosed
WO-2006094357-A1 FLAVONOID COMPOUNDS AND USES THEREOF HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) 2006-09-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof ABCC4, NCOA4, NR4A3 MEN1 4281/4885KMT2A 4362/4885CYP3A4 17/4885
US-20250195452-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE ESR2, ESR1, ESRRB MEN1 2127/4885KMT2A 4051/4885CYP3A4 210/4885
US-20080021096-A1 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY FOS, CREBBP, CREB1 MEN1 3520/4885KMT2A 1152/4885CYP3A4 4468/4885
US-12534742-B2 Compound for regulating gene editing efficiency and application thereof ERG, APOBEC3A, APOBEC3C MEN1 2980/4885KMT2A 799/4885CYP3A4 280/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.