Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30023094 | 0.87 | KMT2A (0.65) | JAK2JAK3KMT2AMEN1ATM | |
| SCHEMBL4377112 | 0.86 | CDK1 (0.61) | JAK2JAK3CDK2CDK1MTOR | |
| SCHEMBL6622738 | 0.84 | CDK2 (0.52) | JAK2JAK3CDK2CDK1MTOR | |
| SCHEMBL30565226 | 0.83 | ROCK1 (0.64) | JAK2JAK3KMT2AMEN1ATM | |
| SCHEMBL3459265 | 0.83 | JAK2 (0.52) | JAK2JAK3CDK2CDK1MTOR | |
| SCHEMBL12423192 | 0.82 | CDK2 (0.53) | JAK2JAK3CDK2CDK1MTOR | |
| SCHEMBL4164569 | 0.81 | CDK2 (0.63) | JAK2JAK3CDK2CDK1MTOR | |
| SCHEMBL25381155 | 0.79 | JAK1 (0.59) | JAK2JAK3CDK2CDK1POLB | |
| SCHEMBL4463575 | 0.78 | PLK4 (0.69) | JAK2JAK3CDK2CDK1SMG1 | |
| SCHEMBL14650506 | 0.78 | JAK2 (0.54) | JAK2JAK3CDK2CDK1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2154967-A1 | PYRIMIDINE DERIVATIVES | Hutchison Medipharma Enterprises Limited (BS) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008128231-A1 | PYRIMIDINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2008-10-23 | — | — | WO | disclosed |