Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27476976 | 0.80 | MEN1 (0.55) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL27473680 | 0.80 | MEN1 (0.55) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL9384154 | 0.80 | MEN1 (0.55) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL27473696 | 0.80 | MEN1 (0.55) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL27473433 | 0.80 | MEN1 (0.55) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL30499386 | 0.80 | MEN1 (0.55) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL3458514 | 0.77 | MAPT (0.43) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL2608577 | 0.77 | BRD4 (0.41) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL2607077 | 0.77 | BRD4 (0.41) | CREBBPBRD4EP300MAPTHTT | |
| SCHEMBL29208930 | 0.75 | ALDH1A1 (0.51) | CREBBPBRD4EP300MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |