Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AIMP2 | Q13155 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 5/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459161 | 0.90 | SRC (0.57) | AIMP2SRCEGFRABL1BCR | |
| SCHEMBL4880015 | 0.87 | AIMP2 (0.57) | AIMP2SRCYES1HRH3CHRNB2 | |
| SCHEMBL3454379 | 0.86 | AIMP2 (0.56) | AIMP2SRCYES1HRH3AXL | |
| SCHEMBL3459641 | 0.85 | AIMP2 (0.50) | AIMP2SRCYES1PDGFRBEGFR | |
| SCHEMBL12190209 | 0.83 | SRC (0.56) | AIMP2SRCYES1HRH3CHRNB2 | |
| SCHEMBL13924599 | 0.81 | SYK (0.65) | AIMP2SRCYES1EGFRABL1 | |
| SCHEMBL3455091 | 0.80 | SYK (0.61) | EGFRPRKCDSCN5ASCN9A | |
| SCHEMBL13924597 | 0.80 | SYK (0.64) | AIMP2SRCYES1HRH3EGFR | |
| SCHEMBL19476605 | 0.80 | IGF1R (0.58) | AIMP2SRCYES1HRH3AXL | |
| SCHEMBL270374 | 0.79 | SRC (0.51) | AIMP2SRCYES1HRH3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2154967-A1 | PYRIMIDINE DERIVATIVES | Hutchison Medipharma Enterprises Limited (BS) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008128231-A1 | PYRIMIDINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2008-10-23 | — | — | WO | disclosed |