Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.74 |
| ▸ | CHRNE | Q04844 | 2/20 | 0.68 |
| ▸ | BCHE | P06276 | 11/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.61 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.61 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.61 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12043414 | 0.85 | ACHE (1.00) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL12043411 | 0.85 | ACHE (0.72) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL30411626 | 0.84 | ACHE (0.70) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL12043412 | 0.84 | ACHE (0.70) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL8015786 | 0.82 | ACHE (0.94) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL8018144 | 0.82 | ACHE (0.68) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL8006390 | 0.81 | ACHE (0.66) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL12043413 | 0.80 | ACHE (0.65) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL9749374 | 0.80 | ACHE (0.65) | ACHECHRNEBCHEGRIN1GRIN2A | |
| SCHEMBL12043407 | 0.78 | ACHE (0.62) | ACHECHRNEBCHEGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803842-B2 | Choline esters useful for the treatment of cognitive dysfunctions and enhancement of memory, learning and cognition | Patel, Hass (US) | 2010-09-28 | — | — | US | disclosed |
| US-20060205815-A1 | Choline esters useful for the treatment of cognitive dysfunctions and enhancement of memory, learning and cognition | PATEL HASMUKH B | 2006-09-14 | — | — | US | disclosed |
| EP-1660434-A1 | CHOLINE ESTERS USEFUL FOR THE TREATMENT OF COGNITIVE DYSFUNCTIONS AND ENHANCEMENT OF MEMORY, LEARNING AND COGNITION | PATEL, Hasmukh B. (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019157-A1 | CHOLINE ESTERS USEFUL FOR THE TREATMENT OF COGNITIVE DYSFUNCTIONS AND ENHANCEMENT OF MEMORY, LEARNING AND COGNITION | PATEL HASMUKH B (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2004045718-A2 | TREATMENT OF COGNITIVE DYSFUNCTIONS' | CYPRESS BIOSCIENCE, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205815-A1 | Choline esters useful for the treatment of cognitive dysfunctions and enhancement of memory, learning and cognition | CHAT, SGMS1, SPTLC1 | ACHE 22/4885CHRNE 56/4885BCHE 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.