SPTLC1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4697866	0.89	2/20
SCHEMBL4697696	0.86	2/20
SCHEMBL4699140	0.80	2/20
SCHEMBL4698636	0.76	2/20
SCHEMBL14217995	0.76	2/20
SCHEMBL14190669	0.75	2/20
SCHEMBL4699183	0.74	2/20
SCHEMBL4696222	0.72	2/20
SCHEMBL14217994	0.72	2/20
SCHEMBL4701699	0.70	2/20
SCHEMBL4920392	0.66	2/20
SCHEMBL6748227	0.64	2/20
SCHEMBL4696804	0.62	2/20
SCHEMBL4701647	0.62	2/20
SCHEMBL14217993	0.61	2/20
SCHEMBL4919390	0.61	2/20
SCHEMBL14070207	0.59	2/20
SCHEMBL14070215	0.59	2/20
SCHEMBL14070277	0.58	2/20
SCHEMBL14069857	0.56	2/20

Clinical trials — most relevant to SPTLC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis	PHASE4	COMPLETED
Hereditary Sensory Neuropathy Serine Trial	PHASE2	UNKNOWN
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo	PHASE2	UNKNOWN
Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Sphingo-lipotoxicity and Trans-differentiation of Adipose Tissue in Obesity (SFINGOTRANS)	nan	COMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV	nan	NOT_YET_RECRUITING
Ceramide Level as Apredictor of Outcomes in Patients of Anterior Myocardial Infarction Undergoing Primary Coronary Intervention	nan	UNKNOWN
Structural Network on Prostate Cancer in the French Greater West Region	nan	COMPLETED
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Plasma Sphingolipid Metabolites and Radiotherapy Efficacy in Hepatocellular Carcinoma	nan	RECRUITING
Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes	nan	COMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Evaluating the Association Between Sphingolipid Metabolites and Post-hepatectomy Liver Failure	nan	COMPLETED
Stearoyl-CoA Desaturase and Energy Metabolism in Humans	nan	COMPLETED
Genomic Dissection of a QTL Affecting the Lipid Profile	nan	WITHDRAWN
Studying Lipids as Potential Biomarkers in Patients With Fabry Disease	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung Disease	nan	NOT_YET_RECRUITING
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)	nan	COMPLETED
Genes Involved in Lipid Disorders	nan	COMPLETED
Biomarker for Farber Disease (BioFarber)	nan	WITHDRAWN
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease	nan	NOT_YET_RECRUITING
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS)	nan	NOT_YET_RECRUITING
Epidemiology of Atherosclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SPTLC1 binder may also engage these)

Protein	Name	Similarity
O54695	—	1.000	O54695 →
D4A2H2	—	1.000	D4A2H2 →
Q3MHG1	—	1.000	Q3MHG1 →
Q60HD1	—	1.000	Q60HD1 →
Q5R9T5	—	1.000	Q5R9T5 →
O35704	—	0.999	O35704 →
Q10P01	—	0.987	Q10P01 →
Q6K8E7	—	0.986	Q6K8E7 →
Q94IB8	—	0.986	Q94IB8 →
Q7G4P2	—	0.981	Q7G4P2 →
P91079	—	0.978	P91079 →
Q6NYL5	—	0.974	Q6NYL5 →
Q8BGT5	—	0.974	Q8BGT5 →
Q6GM82	—	0.972	Q6GM82 →
Q7XQ85	—	0.972	Q7XQ85 →
P17735	—	0.971	P17735 →
P70712	—	0.971	P70712 →
Q58CZ9	—	0.971	Q58CZ9 →
Q9S7E9	—	0.969	Q9S7E9 →
Q28DB5	—	0.968	Q28DB5 →
Q8TD30	—	0.967	Q8TD30 →
Q8QZR1	—	0.967	Q8QZR1 →
Q7XHL3	—	0.967	Q7XHL3 →
P04694	—	0.967	P04694 →
Q07262	—	0.966	Q07262 →
P14173	—	0.965	P14173 →
Q28EN2	—	0.965	Q28EN2 →
Q9CXF0	—	0.964	Q9CXF0 →
Q06086	—	0.964	Q06086 →
Q9C969	—	0.964	Q9C969 →