Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946791 | 0.93 | HPGD (0.51) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL968750 | 0.84 | KMT2A (0.52) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL10181157 | 0.84 | KMT2A (0.47) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL10180464 | 0.84 | KMT2A (0.47) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL10327450 | 0.83 | HPGD (0.42) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL964493 | 0.83 | ALDH1A1 (0.51) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL10327338 | 0.83 | ALDH1A1 (0.43) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL968748 | 0.83 | KMT2A (0.57) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL14421501 | 0.82 | SMN1; SMN2 (0.49) | KMT2AHPGDMEN1PKMSMN1; SMN2 | |
| SCHEMBL10180462 | 0.82 | SMN1; SMN2 (0.49) | KMT2AHPGDMEN1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |