Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459285 | 0.84 | LMNA (0.56) | SMN1; SMN2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL12321866 | 0.82 | MEN1 (0.53) | SMN1; SMN2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL8075835 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2HSD17B10LMNAGAAPPARG | |
| SCHEMBL3461160 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2HSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL3461179 | 0.73 | MEN1 (0.39) | SMN1; SMN2KDM4ELMNAGAAL3MBTL1 | |
| SCHEMBL28736253 | 0.68 | SMN1; SMN2 (0.68) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL3452412 | 0.68 | HRH4 (0.53) | SMN1; SMN2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL30811861 | 0.67 | LMNA (0.57) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL13329877 | 0.67 | LMNA (0.77) | SMN1; SMN2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL28202910 | 0.67 | CLK4 (0.47) | SMN1; SMN2LMNAGAAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EXELIXIS, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EEF2K, RPS6KA3, MTOR | SMN1; SMN2 2850/4885HSD17B10 3945/4885KDM4E 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.