Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459621 | 0.93 | MAPT (0.45) | IDH2MAPTTP53RXFP1LMNA | |
| SCHEMBL966533 | 0.88 | MAPT (0.42) | IDH2MAPTTP53RXFP1LMNA | |
| SCHEMBL968750 | 0.88 | KMT2A (0.52) | MAPTTP53RXFP1LMNAKMT2A | |
| SCHEMBL10327463 | 0.81 | LMNA (0.46) | IDH2MAPTTP53LMNAKMT2A | |
| SCHEMBL966531 | 0.80 | MAPT (0.46) | IDH2MAPTTP53RXFP1LMNA | |
| SCHEMBL968748 | 0.80 | KMT2A (0.57) | MAPTTP53RXFP1LMNAKMT2A | |
| SCHEMBL3459098 | 0.78 | IDH2 (0.52) | IDH2MAPTTP53LMNAKMT2A | |
| SCHEMBL967987 | 0.76 | MAPT (0.44) | MAPTTP53RXFP1LMNAKMT2A | |
| SCHEMBL3459093 | 0.74 | IDH2 (0.52) | IDH2MAPTTP53LMNAKMT2A | |
| SCHEMBL3459112 | 0.74 | HPGD (0.46) | MAPTTP53RXFP1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |