Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | XBP1 | P17861 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964028 | 0.94 | LMNA (0.44) | MAPTLMNAALDH1A1XBP1KMT2A | |
| SCHEMBL965220 | 0.91 | GRK2 (0.47) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL965312 | 0.91 | GRK2 (0.47) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL3460785 | 0.86 | GRK2 (0.47) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL968750 | 0.85 | KMT2A (0.52) | GRK2MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL965577 | 0.84 | ALDH1A1 (0.44) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL965578 | 0.84 | ALDH1A1 (0.44) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL965219 | 0.84 | ALDH1A1 (0.47) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL967168 | 0.84 | ALDH1A1 (0.47) | GRK2MAPTLMNAALDH1A1XBP1 | |
| SCHEMBL967167 | 0.84 | ALDH1A1 (0.47) | GRK2MAPTLMNAALDH1A1XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |