Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463033 | 1.00 | NAMPT (0.49) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL17055941 | 0.82 | POLB (0.55) | NAMPTSMN1; SMN2KMT2AKDM4EPBK | |
| SCHEMBL8234022 | 0.81 | LMNA (0.62) | SMN1; SMN2LMNAKDM4ECYP1A2HPGD | |
| SCHEMBL22230378 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL30880731 | 0.78 | NAMPT (0.50) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL28801038 | 0.77 | NAMPT (0.60) | NAMPTSMN1; SMN2KDM4EPBKCYP1A2 | |
| SCHEMBL3462385 | 0.77 | SMYD3 (0.55) | SMN1; SMN2LMNAALDH1A1KMT2AKDM4E | |
| SCHEMBL3460000 | 0.77 | SMYD3 (0.55) | SMN1; SMN2LMNAALDH1A1KMT2AKDM4E | |
| SCHEMBL21722742 | 0.76 | MAPT (0.47) | SMN1; SMN2LMNAKDM4ECYP1A2HPGD | |
| SCHEMBL30880780 | 0.76 | MAPT (0.47) | SMN1; SMN2LMNAKDM4ECYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | NAMPT 2400/4885SMN1; SMN2 4557/4885LMNA 3773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.