Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460636 | 1.00 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CGPIK3CBEGFR | |
| SCHEMBL3461074 | 0.88 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CGPIK3CBEGFR | |
| SCHEMBL3461054 | 0.88 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CGPIK3CBEGFR | |
| SCHEMBL3461621 | 0.86 | ATR (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461822 | 0.86 | ATR (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461268 | 0.86 | ATR (0.57) | PIK3CDPIK3CAPIK3CGPRKDCATM | |
| SCHEMBL14237314 | 0.85 | ATR (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL3461732 | 0.84 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBEGFR | |
| SCHEMBL3461942 | 0.84 | HPGDS (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL3462527 | 0.81 | CFD (0.58) | PIK3CDPIK3CAPIK3CGPIK3CBATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | PIK3CD 375/4885PIK3CA 463/4885PIK3CG 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.