Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055145 | 1.00 | GCK (0.47) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1056454 | 0.84 | GCK (0.52) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL421885 | 0.82 | GCK (0.43) | GCKKCNH2RARARARB | |
| SCHEMBL2669700 | 0.81 | GCK (0.52) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL423126 | 0.81 | GCK (0.52) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL13127258 | 0.80 | GCK (0.57) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL425598 | 0.80 | GCK (0.41) | GCKKCNH2RARARARB | |
| SCHEMBL428556 | 0.79 | GCK (0.48) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL423252 | 0.77 | GCK (0.41) | GCKKCNH2 | |
| SCHEMBL426478 | 0.77 | MMP2 (0.41) | GCKCYP3A4RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2239253-A1 | NOVEL PHENYLPYRROLE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-10-13 | — | — | EP | disclosed |