Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 7/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 5/20 | 0.40 |
| ▸ | MERTK | Q12866 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463408 | 1.00 | TYRO3 (0.42) | TYRO3SYKSTK17ASTK17BSELP | |
| SCHEMBL3448900 | 0.84 | CSNK2A1 (0.46) | TYRO3SYKSELPCSNK2A1LRRK2 | |
| SCHEMBL3449243 | 0.84 | CSNK2A1 (0.46) | TYRO3SYKSELPCSNK2A1LRRK2 | |
| SCHEMBL3451208 | 0.81 | EGFR (0.44) | TYRO3STK17ASTK17BLRRK2EGFR | |
| SCHEMBL3447987 | 0.81 | EGFR (0.44) | TYRO3STK17ASTK17BLRRK2EGFR | |
| SCHEMBL3463402 | 0.81 | TYRO3 (0.43) | TYRO3SYKSTK17ASELPLRRK2 | |
| SCHEMBL3450787 | 0.81 | EGFR (0.41) | TYRO3SYKSTK17ASELPLRRK2 | |
| SCHEMBL3450789 | 0.81 | EGFR (0.41) | TYRO3SYKSTK17ASELPLRRK2 | |
| SCHEMBL3450057 | 0.80 | IRAK4 (0.42) | TYRO3SYKSELPCSNK2A1LRRK2 | |
| SCHEMBL3449272 | 0.79 | EGFR (0.43) | TYRO3SYKSELPCSNK2A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | TYRO3 2798/4885SYK 804/4885STK17A 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.