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SCHEMBL3463775

SCHEMBL3463775

Cc1cc(O[C@H]2CC(C(=O)NO)C(C(=O)N3CC=C(c4ccccc4)C3)N(C)C2)c2ccccc2n1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 13/20 0.46
▸ ADAM10 O14672 11/20 0.46
▸ ERBB2 P04626 10/20 0.46
▸ MMP9 P14780 8/20 0.45
▸ ADAM17 P78536 4/20 0.45
▸ MMP3 P08254 7/20 0.43
▸ MMP1 P03956 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2174859 1.00 MMP2 (0.46) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL3463786 1.00 MMP2 (0.46) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL3463771 1.00 MMP2 (0.46) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL2172622 0.94 ADAM10 (0.53) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL2176122 0.88 ADAM10 (0.46) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL2175598 0.85 ADAM10 (0.61) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL2172538 0.84 ADAM10 (0.55) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL2173070 0.84 ADAM10 (0.48) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL2174786 0.83 ADAM10 (0.63) MMP2ADAM10ERBB2MMP9ADAM17
SCHEMBL5666968 0.83 ADAM10 (0.63) MMP2ADAM10ERBB2MMP9ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2264030-A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases Incyte Corporation (US) 2010-12-22 — — EP claimed