SCHEMBL346500

SCHEMBL346500

O=C(O)/C=C\C(=C/C(=O)O)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.53
TP53 P04637 1/20 0.53
EGLN1 Q9GZT9 1/20 0.53
EGLN3 Q9H6Z9 1/20 0.53
HCAR2 Q8TDS4 8/20 0.37
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
GAA P10253 1/20 0.32
ALOX15 P16050 1/20 0.32
RECQL P46063 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GABRR1 P24046 2/20 0.32
GABRR2 P28476 2/20 0.32
BLM P54132 2/20 0.32
GABRR3 A8MPY1 1/20 0.32
LMNA P02545 1/20 0.32
APEX1 P27695 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2721423 1.00 TSHR (0.53) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL346501 1.00 TSHR (0.53) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL21775463 1.00 TSHR (0.53) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL28157428 0.78 TSHR (0.33) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL9311666 0.77 TSHR (0.53) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL2351110 0.73 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL344295 0.73 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL344296 0.73 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL16234752 0.73 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL3777151 0.73 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4341330-B1 PROCESS FOR MANUFACTURING A THERMOSET POLYMER FOAM AND POLYMER FOAM PLANTICS HOLDING B V (NL) 2025-02-19 EP claimed
EP-4341330-A1 PROCESS FOR MANUFACTURING A THERMOSET POLYMER FOAM AND POLYMER FOAM Plantics Holding B.V. (NL) 2024-03-27 EP claimed
US-20230303784-A1 PROCESS FOR PRODUCING A NON-FLAT ARTICLE Plantics Holding B.V. (NL) 2023-09-28 US claimed
WO-2022243293-A1 Process for manufacturing a thermoset polymer foam and polymer foam Plantics Holding B.V. (NL) 2022-11-24 WO claimed
WO-2022221338-A2 SYSTEMS, MICROORGANISMS, OR METHODS FOR WASTE PET VALORIZATION WASHINGTON UNIVERSITY (US) 2022-10-20 WO claimed
US-20170275655-A1 CONVERSION OF BIOMASS TO USEFUL INTERMEDIATES Alliance for Energy Innovation, LLC 2017-09-28 US claimed
WO-2016036915-A1 GENETICALLY MODIFIED MICROBES FOR THE BIOLOGICAL CONVERSION OF CARBONACEOUS MATERIALS TO PROTOCATECHUIC ACID COFFA GIANGUIDO (US) 2016-03-10 WO claimed
CN-122081068-A Lignin degrading microorganism and separation method and application thereof 2026-05-26 CN disclosed
WO-2025262063-A1 BIODEGRADABLE PACKAGING MATERIAL AND POLYESTER (PRE)POLYMERS FOR THE MAKING THEREOF WP TRADING ALPHEN AAN DEN RIJN B.V. (NL) 2025-12-26 WO disclosed
CN-116096857-B Biosynthesis of commodity chemicals from oil palm empty fruit cluster lignin 新加坡国立大学 2025-09-12 CN disclosed
EP-4598992-A1 PROCESS FOR PROCESSING POLYMER-CONTAINING MATERIALS Plantics Holding B.V. (NL) 2025-08-13 EP disclosed
EP-4532165-A1 METHOD FOR MANUFACTURING FILLER-CONTAINING COMPOSITIONS WITH A SPECIFIC CURING REGIMEN Plantics Holding B.V. (NL) 2025-04-09 EP disclosed
WO-2025066218-A1 GENETICALLY ENGINEERED BACTERIUM FOR DE NOVO SYNTHESIS OF CIS,CIS-MUCONIC ACID BY USING GLUCOSE AS SUBSTRATE AND USE THEREOF 北京化工大学 2025-04-03 WO disclosed
EP-1887081-A2 DNA Sequences Ceres Incorporated (US) 2008-02-13 EP disclosed
EP-1586645-A2 Sequence-determined DNA fragments and corresponding polypeptides encoded thereby Ceres Incorporated (US) 2005-10-19 EP disclosed
US-6385546-B1 Stabilizing and destabilizing proteins RUTGERS, THE UNIVERSITY OF NEW JERSEY 2002-05-07 US disclosed
EP-1059354-A2 Sequence-determined DNA fragments and corresponding polypeptides encoded thereby Ceres Incorporated (US) 2000-12-13 EP disclosed
EP-1033405-A2 Sequence-determined DNA fragments and corresponding polypeptides encoded thereby Ceres Incorporated (US) 2000-09-06 EP disclosed
US-4608338-A OXIDIZING TOLUENE TO MUCONIC ACIDK, REDUCING TO ADIPIC ACID; PSEUDOMONA MUTANTS CELANESE CORPORATION (US) 1986-08-26 US disclosed
US-4480034-A OXIDATION OF AROMATIC HYDROCARBON TO CARBOXYLIC ACID CELANESE CORPORATION (US) 1984-10-30 US disclosed