Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.82 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2397939 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL2397933 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL344295 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL3777151 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL16234752 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28510554 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145325 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145327 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL27799964 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL27770053 | 0.96 | TSHR (0.75) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 632 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118415803-B | Integrated valve, intragastric balloon, preparation method of integrated valve and intragastric balloon and weight-losing balloon set | 杭州糖吉医疗科技有限公司 | 2024-09-27 | — | — | CN | claimed |
| CN-118620502-A | Polyurea finish paint material resistant to disinfectant, and preparation method and application thereof | 江门市长河化工实业集团有限公司 | 2024-09-10 | — | — | CN | claimed |
| CN-108699324-B | Polymeric composition for fiber optic cable assemblies | 陶氏环球技术有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-114624794-B | Protective film for display screen polaroid and production method | 佛山市顺德区明本新型材料科技有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-116507204-A | Method for preparing microcapsules | 西姆莱斯股份公司 | 2023-07-28 | — | — | CN | claimed |
| WO-2023118472-A1 | COATED PAPERBOARD | BILLERUD AKTIEBOLAG (PUBL) (SE) | 2023-06-29 | — | — | WO | claimed |
| EP-4202118-A1 | COATED PAPERBOARD | Billerud Aktiebolag (publ) (SE) | 2023-06-28 | — | — | EP | claimed |
| CN-113880976-B | Ethylene maleic anhydride alternating copolymer and application of hydrolysate thereof in preparation of silicon negative electrode material | 中山大学 | 2023-06-23 | — | — | CN | claimed |
| WO-2023107666-A1 | DEVICE FOR REVERSIBLY BLOCKING ACTIVITIES OF TARGET REGION AND APPLICATIONS OF SAME | NORTHWESTERN UNIVERSITY (US) | 2023-06-15 | — | — | WO | claimed |
| CN-115975559-A | Adhesive resin, method for producing the same, and protective film | 广州鹿山新材料股份有限公司 | 2023-04-18 | — | — | CN | claimed |
| WO-2002080801-A2 | ELASTOMERIC MONOFILAMENT DENTAL TAPES | PERI-DENT LIMITED (GB) | 2002-10-17 | — | — | WO | claimed |
| US-20020144704-A1 | Elastomeric monofilament dental tapes | PERI-DENT LIMITED (GB) | 2002-10-10 | — | — | US | claimed |
| US-20020137850-A1 | Hybrid polymers for phase change ink jet inks | WESTVACO CORPORATION, NEW YORK, NY | 2002-09-26 | — | — | US | claimed |
| US-20020086933-A1 | Hybrid polymers for phase change ink jet inks | WESTVACO CORPORATION (US) | 2002-07-04 | — | — | US | claimed |
| WO-2001088050-A2 | ADHESIVE COMPOSITIONS FOR BONDING PASSIVE SUBSTRATES SUCH AS MAGNESIUM ALLOYS | HENKEL LOCTITE CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |
| EP-0988517-A2 | DETECTION OF CHEMICAL AGENT MATERIALS USING A SORBENT POLYMER AND FLUORESCENT PROBE | Calspan Corporation (US) | 2000-03-29 | — | — | EP | claimed |
| WO-1999001737-A9 | DETECTION OF CHEMICAL AGENT MATERIALS USING A SORBENT POLYMER AND FLUORESCENT PROBE | CALSPAN CORP (US) | 1999-05-20 | — | — | WO | claimed |
| WO-1999001737-A2 | DETECTION OF CHEMICAL AGENT MATERIALS USING A SORBENT POLYMER AND FLUORESCENT PROBE | CALSPAN CORPORATION (US) | 1999-01-14 | — | — | WO | claimed |
| US-5599871-A | INCLUDING POLYHEXAMETHYLENE ADIPAMIDE, POLYAMIDE COPOLYMER, THERMOPLASTIC ELASTOMER, COPOLYMER OF ETHYLENE AND TETRAFLUOROETHYLENE, AMIDE WAX | HYUNDAI MOTOR COMPANY (KR) | 1997-02-04 | — | — | US | claimed |
| US-4252656-A | AEROSOL CONTAINING CATIONIC POLYMER, SOFTENING AND FOAMING AGENTS, STABILIZER, HUMECTANT, WATER, AND PROPELLANT; LAUNDRY DRIERS | COLGATE-PALMOLIVE COMPANY (US) | 1981-02-24 | — | — | US | claimed |