⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236097 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL9426341 | 0.80 | ALDH1A1 (0.37) | — | |
| SCHEMBL5070970 | 0.78 | — | — | |
| SCHEMBL12940281 | 0.78 | — | — | |
| SCHEMBL11528230 | 0.77 | ALDH1A1 (0.36) | — | |
| SCHEMBL15375030 | 0.76 | — | — | |
| SCHEMBL12249052 | 0.76 | SIGMAR1 (0.38) | — | |
| SCHEMBL1276604 | 0.76 | — | — | |
| SCHEMBL10520855 | 0.75 | CYP2C9 (0.44) | — | |
| SCHEMBL7756313 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240602-A1 | METHODS AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | BURKE THOMAS G | 2010-09-23 | — | — | US | claimed |
| EP-1372571-A4 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1372571-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | New Century Pharmaceuticals, Inc. (US) | 2004-01-02 | — | — | EP | claimed |
| US-20020193318-A1 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | NEW CENTURY PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | claimed |
| WO-2002074246-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS, INC. (US) | 2002-09-26 | — | — | WO | claimed |
| US-10201617-B2 | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2019-02-12 | — | — | US | disclosed |
| US-9962452-B2 | Soluble complexes of drug analogs and albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2018-05-08 | — | — | US | disclosed |
| US-9937259-B2 | Abiraterone derivatives and non-covalent complexes with albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2018-04-10 | — | — | US | disclosed |
| US-20170319708-A1 | 3-Substituted Piperidine-2, 6-Diones and Non-Covalent Complexes with Albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2017-11-09 | — | — | US | disclosed |
| US-20170216443-A1 | ABIRATERONE DERIVATIVES AND NON-COVALENT COMPLEXES WITH ALBUMIN | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2017-08-03 | — | — | US | disclosed |
| WO-2015200837-A1 | ABIRATERONE DERIVATIVES AND NON-COVALENT COMPLEXES WITH ALBUMIN | FL THERAPEUTICS LLC (US) | 2015-12-30 | — | — | WO | disclosed |
| US-20150366984-A1 | SOLUBLE COMPLEXES OF DRUG ANALOGS AND ALBUMIN | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2015-12-24 | — | — | US | disclosed |
| US-20100240602-A1 | METHODS AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | BURKE THOMAS G | 2010-09-23 | — | — | US | disclosed |
| US-7691872-B2 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1372571-A4 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1372571-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | New Century Pharmaceuticals, Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20020193318-A1 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | NEW CENTURY PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | disclosed |
| WO-2002074246-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS, INC. (US) | 2002-09-26 | — | — | WO | disclosed |
| US-4315846-A | FUNGICIDES | TOKYO ORGANIC CHEMICAL INDUSTRIES, LTD. (JP) | 1982-02-16 | — | — | US | disclosed |
| EP-0037861-A1 | Salts of alkylenebisdithiocarbamic acid derivatives, processes for their preparation, fungicidal compositions containing them and methods of combating fungi | TOKYO ORGANIC CHEMICAL INDUSTRIES, LTD. (JP) | 1981-10-21 | — | — | EP | disclosed |