SCHEMBL3466464

SCHEMBL3466464

COCCNc1nccn2c(-c3cccc(O)c3)cnc12

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TTK P33981 16/20 0.48
FLT3 P36888 2/20 0.44
FYN P06241 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3470355 0.87 CYP1A2 (0.53) TTKFLT3FYN
SCHEMBL3466151 0.83 TTK (0.62) TTKFLT3
SCHEMBL5420238 0.82 FLT3 (0.52) TTKFLT3FYN
SCHEMBL3470277 0.82 FYN (0.54) TTKFLT3FYN
SCHEMBL12409323 0.81 PIK3CA (0.46) TTKFLT3FYN
SCHEMBL3466360 0.80 TTK (0.53) TTKFLT3
SCHEMBL3469144 0.80 TTK (0.61) TTKFYN
SCHEMBL12409229 0.80 TTK (0.51) TTKFYN
SCHEMBL12409318 0.78 ADORA3 (0.52) TTKFYN
SCHEMBL12409294 0.77 TTK (0.61) TTKFLT3FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010069684-A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA, LTD. (BS) 2010-06-24 WO claimed
WO-2010069684-A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA, LTD. (BS) 2010-06-24 WO disclosed