Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | KATNA1 | O75449 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18848885 | 0.83 | TNKS (0.44) | CYP11B1KDM1ATNKSRXFP1NPC1 | |
| SCHEMBL3342956 | 0.81 | CYP11B1 (0.52) | CYP11B1KDM1AKATNA1NPC1RAB9A | |
| SCHEMBL3466788 | 0.80 | CASP1 (0.50) | CYP11B1KDM1ATNKSRXFP1PTGER4 | |
| SCHEMBL7232835 | 0.79 | CCR1 (0.58) | CYP11B1KATNA1NPC1RAB9ACASP3 | |
| SCHEMBL375549 | 0.79 | DYRK1A (0.53) | NPC1RAB9ACASP3SENP7DYRK1A | |
| SCHEMBL30955282 | 0.79 | CYP3A4 (0.53) | CYP11B1KDM1AKATNA1NPC1RAB9A | |
| SCHEMBL17754087 | 0.78 | RXFP1 (0.54) | CYP11B1KDM1ARXFP1NPC1RAB9A | |
| SCHEMBL23154072 | 0.77 | RXFP1 (0.42) | KDM1ATNKSRXFP1NPC1RAB9A | |
| SCHEMBL27436328 | 0.76 | CYP11B1 (0.48) | CYP11B1KDM1AKATNA1NPC1RAB9A | |
| SCHEMBL8023947 | 0.76 | PTGER4 (0.48) | CYP11B1TNKSRXFP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |