Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CBFB | Q13951 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994452 | 0.80 | RAB9A (0.47) | PTGER4CYP11B1CYP11B2CASP3SENP7 | |
| SCHEMBL8007166 | 0.79 | P2RX7 (0.44) | P2RX7S1PR1 | |
| SCHEMBL8007163 | 0.77 | CASP3 (0.56) | PTGER4RXFP1CBFBCYP11B1CYP11B2 | |
| SCHEMBL7941960 | 0.76 | P2RX7 (0.46) | P2RX7NPC1RAB9AKDM4ES1PR1 | |
| SCHEMBL8028548 | 0.76 | KDM4E (0.47) | P2RX7KDM4EALDH1A1 | |
| SCHEMBL3127408 | 0.76 | ALDH1A1 (0.47) | CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL3466792 | 0.76 | CYP11B1 (0.49) | PTGER4RXFP1CYP11B1CYP11B2TNKS | |
| SCHEMBL16675774 | 0.75 | FYN (0.58) | CBFBCYP11B1CYP11B2FYN | |
| SCHEMBL7946481 | 0.75 | CYP11B1 (0.48) | PTGER4CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL18848885 | 0.75 | TNKS (0.44) | PTGER4RXFP1CYP11B1CYP11B2TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |