Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467686 | 0.80 | KDM4E (0.38) | CYP11B2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2117206 | 0.69 | SYK (0.46) | MAPTALDH1A1CASP1PARP1KDM4E | |
| SCHEMBL2119855 | 0.67 | MEN1 (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2120158 | 0.66 | TP53 (0.40) | MAPTMEN1KMT2ACHUK | |
| SCHEMBL2117885 | 0.66 | ALDH1A1 (0.37) | MAPTALDH1A1MEN1KMT2ACHUK | |
| SCHEMBL5224060 | 0.66 | PARP1 (0.46) | ALDH1A1PARP1GRM2MYCXDH | |
| SCHEMBL30116316 | 0.65 | DHODH (0.66) | MAPTCHUKDHODHPARP1L3MBTL1 | |
| SCHEMBL2767509 | 0.65 | S1PR3 (0.50) | CYP11B2PARP1 | |
| SCHEMBL501850 | 0.64 | PARP1 (0.60) | MAPTALDH1A1KMT2ADHODHPARP1 | |
| SCHEMBL12865158 | 0.64 | PARP1 (0.60) | MAPTALDH1A1DHODHPARP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |