Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404986 | 0.80 | FLT3 (0.52) | FLT3CYP1A2ADORA3CYP3A4CYP2C19 | |
| SCHEMBL3470436 | 0.79 | TTK (0.52) | FLT3ADORA3TTK | |
| SCHEMBL3466960 | 0.77 | EED (0.50) | NPC1RAB9ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL12409322 | 0.74 | ZAP70 (0.47) | NPC1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3469537 | 0.73 | FYN (0.51) | RAB9ACYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3466848 | 0.72 | FLT3 (0.43) | FLT3CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5404980 | 0.72 | MAPT (0.41) | CYP1A2CYP3A4CYP2C19CYP2D6LMNA | |
| SCHEMBL3466521 | 0.72 | LMNA (0.41) | NPC1RAB9AFLT3CYP1A2CYP3A4 | |
| SCHEMBL9940986 | 0.71 | TTK (0.75) | TTK | |
| SCHEMBL8246878 | 0.70 | FYN (0.47) | FLT3CYP1A2ADORA3EGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |